Comparison of Clomiphene Citrate Alone with Combination of Clomiphene Citrate Plus Gonadotropin in Achieving Pregnancy with Unexplained Infertility

Abstract

Background: Infertility is the most common problem faced by couples now days. According to statistics 2023 approximately 48.5 million couples faced infertility worldwide.

Objective: Our study's objective was to examine the effectiveness of clomiphene citrate alone vs a combination of clomiphene citrate and gonadotropin in helping patients with unexplained infertility become pregnant.

Methods: : : A total of seventy-two patients, 20 to 35 years of age with unexplained infertility were included, through a randomized control trial in MCH center of PIMS, Islamabad. Patients with history of taking medicines such dopamine dilators, dopamine receptor blockers, H-2 blockers, and verapamil as well as other reasons of infertility included tubal factors, male factors, and hyperprolactinemia were excluded. All patients were divided into two groups i.e. Group A (clomiphene citrate) & Group B (clomiphene citrate plus gonadotropin). Outcome variables like efficacy i.e. occurrence of pregnancy, were noted.

Results: In groups A and B the mean age  was 26.73 3.49 and 27.20 3.35, respectively. The average marriage lasted 4.17 ± 2.12 years in group A and 4.39 2.27 years in group B. Group A (the clomiphene citrate group) efficacy was 15 (41%) while Group B (the combination of clomiphene citrate and gonadotropin) efficacy was 28 (77%) with a p-value of 0.005.

Conclusion: The conclusion of the study was that efficacy of clomiphene citrate plus gonadotropin combination in achieving pregnancy in patients with unexplained infertility is higher compared to clomiphene citrate only.